Preparation of a Traditional Poly Herbal Gel for Abnormal Vaginal Discharge

Background and objectives: Plants are usually used for treatment of different diseases according to their traditional application. The use of the plant based medications is increasingly becoming popular all over the world. Traditional herbal medicines should be transformed into new forms to make better acceptance and more comfortable use by patients. The aim of the present study was to formulate a poly herbal gel based on Iranian traditional medicine (ITM), and determine its physicochemical characteristics. Methods: The gel formulation consisted of Boswellia spp., Carum carvi L., Punica granatum L. and Myrtus communis L. extracts. The product was evaluated for the physicochemical parameters. The laboratory stability tests, microbiological tests and rheological behavior were performed on the gel. Additionally, total tannin content of the gel was measured as pyrogallol using Folin-Ciocalteu reagent and hide powder. Results: Stability and physicochemical evaluations as well as microbiological tests showed that the prepared formulation was stable towards physical changes with no growth of pathogenic microorganisms. Moreover, it represented plastic behavior which is in favor of a topical product and alsototal tannins contents were determined to be 0.27 % in the gel. Conclusion: The product was acceptable due to its physical characterisitcs and so appropriate for topical use. Regarding the antibacterial, antifungal and anti-inflammatory properties of the medicinal herbs in the gel and also, the role of tannins as astringent agents, this formulation could be a suitable candidate for abnormal vaginal discharge with regards to its traditional application in ITM.